Flash point (FP) is the primary property to classify flammable liquids for the purpose of assessing their fire and explosion hazards Because of the advancement of technology in discovering or synthesizing new compounds, there is often a significant gap between the demand for such data and their availability In this regard, reliable methods to estimate the FP of a compound arc indispensible In this work, a quantitative structure property relationship study is presented for predicting the FP of organosilicon compounds To build up and validate the proposed models, a data set of 230 organosilicon compounds are collected and divided into a training set of 184 compounds and a testing set of 46 compounds The stepwise regression method is used to select the required molecular descriptors for predicting the FP of organosilicon compounds from 1538 molecular descriptors Depending on the p-value for accepting a descriptor to enter the model, models with different number of descriptors are obtained A 13-descriptor model and a 6-descriptor model are obtained with the p-value of 5 x 10(-4) and 1 x 10(-5), respectively It is found that the 6-descriptor model could fit the training data with R-2 = 0 8981 and predict the test data with Q(2) = 0 8533 and the 13-descriptor model could fit the training data with R-2 = 0 9293 and predict the test data with Q(2) = 0 9245 The average predictive errors are less than 5% for both proposed models and they are useful for many practical applications, because the proposed models used only calculated descriptors from the molecular structure