Because of its generality, thermodynamics is applicable to all substances, including biomacromolecules. To illustrate how thermodynamics can contribute to biotechnology, each of six examples gives a brief summary of pertinent, previously published research. Each example indicates that familiar concepts in chemical engineering thermodynamics can be applied to contribute toward solution of a practical problem. These examples are discussed here to encourage thermodynamically oriented chemical engineers to devote their talents toward helping to advance industrial biotechnology.