Liquid cooling is an efficient way to remove heat fluxes with magnitudes up to 10,000 W/cm(2). One limitation of current single-phase microchannel heat sinks is the relatively low Nusselt number, due to laminar flow. In this work, we experimentally investigate how to enhance the Nusselt number with the introduction of segmented flow. The segmented flow pattern was created by the periodic injection of air bubbles through a T-junction into water-filled channels. We designed a polycarbonate heat sink consisting of an array of seven parallel microchannels each with a square cross-section 500 pm wide. We show that segmented flow increases the Nusselt number of laminar flow by more than 100%, provided the mass velocity of the liquid is within the range 330-2000 kg/m(2) s. (C) 2010 Elsevier Ltd. All rights reserved.