The cotton crosslinking with butane tetra carboxylic acid (BTCA) and citric acid (CA) in the presence of sodium hypophosphite (SHP) and nano TiO2 (NTO) under different curing conditions were optimized using a statistical model. The central composite design (CCD) was used for variables based on Design of Expert software. The appropriate model to create optimum crease recovery angle was obtained for each condition. The X-ray diffraction (XRD) and scanning electron microscopy (SEM) were also employed to indicate the NTO particles on the fabric surface with the size of nano particles and their crystallinity. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 117: 2740-2748, 2010