화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.28, No.4, 1110-1119, April, 2011
DOI10.1007/s11814-010-0475-1  Export Citation
Solvent-gradient SMB to separate o-xylene and p-xylene
Nguyen Van Duc Long1, Ju Weon Lee2, 3, Thai-Hoang Le1, Jin-Il Kim1, and Yoon-Mo Koo1, 3, †
  • 1Department of Biological Engineering, Inha University, 253 Younghyun-dong, Namgu, Incheon 402-751, Korea
  • 2Department of Chemical Engineering, Inha University, 253 Younghyun-dong, Namgu, Incheon 402-751, Korea
  • 3Center for Advanced Bioseparation Technology, Inha University, 253 Younghyun-dong, Namgu, Incheon 402-751, Korea
E-mail:
In batch chromatography, solvent-gradient operations (SG) produce significant improvement in terms of the enrichment of products and the separation time and the solvent consumption as compared with isocratic operations. This work studied solvent-gradient operation in reversed-phase simulated moving bed unit to separate ortho-xylene and para-xylene. In a solvent-gradient mode, different mobile phase compositions lead to a different retention behavior of solutes, i.e., different adsorption isotherms. Frontal analysis experiments for ortho-xylene and para-xylene were carried out with a reversed-phase column to measure adsorption parameters at several different mobile phase compositions, such as 45%, 50%, 60%, 75% and 90% acetonitrile. Therefore, the parameters in the retention model for solvent-gradient operation in the case of reversed-phase chromatography were estimated and applied to the design of an SMB system. A modified design method for solvent-gradient simulated moving bed chromatography (SG-SMB) was proposed. The robust operating conditions were obtained within the separation region on (φR, φE) plane (φR and φE are the volumetric content of organic modifier in the raffinate and the extract streams, respectively). The performance results of isocratic and solvent-gradient SMB were compared. A partial-discard strategy and increasing of the solvent gradient level were also applied to improve the performance of the SG-SMB.
Keywords:Solvent-gradient;Simulated Moving Bed;SMB;O-xylene;P-xylene;Reversed Phase Liquid Chromatography
  1. Broughton DB, Gerhold CG, U.S. Patent, 2,985,589 (1961)
  2. Pais LS, Loureiro JM, Rodrigues AE, J. Chromatogr. A., 827, 215 (1998)
  3. Azevedo DCS, Rodrigues AE, AIChE J., 47(9), 2042 (2001)
  4. Juza M, Mazzotti M, Morbidelli M, J. Trends Biotechnol., 18, 108 (2000)
  5. Schulte M, Strube JP, J. Chromatogr. A., 906, 399 (2001)
  6. Migliorini C, Wendlinger M, Mazzotti M, Morbidelli M, Ind. Eng. Chem. Res., 40(12), 2606 (2001)
  7. Mazzotti M, Storti G, Morbidelli M, J. Chromatogr. A., 786, 309 (1997)
  8. Abel S, Mazzotti M, Morbidelli M, J. Chromatogr. A., 944, 23 (2002)
  9. Abel S, Mazzotti M, Morbidelli M, J. Chromatogr. A., 1026, 47 (2004)
  10. Jensen TB, Reijns TGP, Billiet HAH, van der Wielen LAM, J. Chromatogr. A., 873, 149 (2000)
  11. Antos D, Seidel-Morgenstern A, Chem. Eng. Sci., 56(23), 6667 (2001)
  12. Antos D, Seidel-Morgenstern A, J. Chromatogr. A., 944, 77 (2002)
  13. Ziomek G, Antos D, J. Chromatogr. A., 29, 1577 (2005)
  14. Ziomek G, Kaspereit M, Jezowski J, Seidel-Morgenstern A, Antos D, J. Chromatogr. A., 1070, 111 (2005)
  15. Storti G, Mazzotti M, Morbidelli M, Carra S, AIChE J., 39, 471 (1993)
  16. Mazzotti M, Storti G, Morbidelli M, J. Chromatogr. A., 769, 3 (1997)
  17. Jin CH, Lee JW, Row KH, J. Sep. Sci., 31, 23 (2008)
  18. Lee JW, Row KH, J. Sep. Sci., 32, 221 (2009)
  19. Guiochon G, Shirazi SG, Katti AM, Academic Press, Boston, MA (1994)
  20. Mihlbachler K, Kaczmarski K, Seidel-Morgenstern A, Guiochon G, J. Chromatogr. A., 955, 35 (2002)
  21. Bae YS, Lee CH, J. Chromatogr. A., 1122, 161 (2006)