Amiodarone aqueous systems at concentrations C <= 3 mg/mL were studied with different techniques (conductivity, solubility, ion-selective electrodes, pH, viscosity, polarizing microscopy, computational simulation, electron microscopy and fluorescence at various temperatures. The Krafft point (T-K = 70.6 degrees C) was determined. A partial phase diagram was plotted showing the critical micelle concentration (CMC) dependence on temperature, the solubility and a transition between a coacervate and an unstable gel below T-K as a function of temperature. The nature of aggregates below T-K at different concentrations was determined. Micellization is an entropy-driven process which is probably caused by a strong dehydration of the amiodarone backbone on micellization. CMC, micelle aggregation number and T-K given in earlier literature were misinterpreted in the original articles and are re-interpreted in this work. (C) 2009 Elsevier Inc. All rights reserved.