Bisphenol A (BPA) is an environmental pollutant to disrupt endocrine system or cause cancer, thus the detection of BPA is very important. Herein, an amperometric sensor was fabricated based on immobilized CoTe quantum dots (CoTe QDs) and PAMAM dendrimer (PAMAM) onto glassy carbon electrode (GCE) surface. The cyclic voltammogram of BPA on the sensor exhibited a well-defined anodic peak at 0.490V in 0.1 M pH 8.0 PBS. The determination conditions were optimized and the kinetic parameters were calculated. The linear range was 1.3 x 10(-8) to 9.89 x 10(-6) M with the correlation coefficient of 0.9999. The limit of detection was estimated to be 1 x 10(-9) M. The current reached the steady-state current within about 5 s. Furthermore, the fabricated sensor was successfully applied to determine BPA in real water samples. (C) 2009 Elsevier B.V. All rights reserved.