Neural implants are technical systems that restore sensory or motor functions after injury and modulate neural behavior in neuronal diseases. Neural interfaces or prostheses have lead to new therapeutic options and rehabilitation approaches in the last 40 years. The interface between the nervous tissue and the technical material is the place that determines success or failure of the neural implant. Recording of nerve signals and stimulation of nerve cells take place at this neuro-technical interface. Polymers are the most common material class for substrate and insulation materials in combination with metals for interconnection wires and electrode sites. This work focuses on the neuro-technical interface and summarizes its fundamental specifications first. The most common polymer materials are presented and described in detail. We conclude with an overview of the different applications and their specific designs with the accompanying manufacturing processes from precision mechanics, laser structuring and micromachining that are introduced in either the peripheral or central nervous system. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 49: 18-33, 2011