Journal of the American Chemical Society, Vol.132, No.6, 1770-1770, 2010
Zinc-Catalyzed Reduction of Amides: Unprecedented Selectivity and Functional Group Tolerance
A novel zinc-catalyzed reduction of tertiary amides was developed. This system shows remarkable chemoselectivity and substrate scope tolerating ester, ether, nitro, cyano, azo, and keto substituents