Journal of the American Chemical Society, Vol.132, No.41, 14330-14333, 2010
A Straightforward Route to Functionalized trans-Diels-Alder Motifs
A sequence consisting of a Lewis acid-catalyzed Diels-Alder reaction on a 2-halocyclohexenone, followed by reductive alkylation, provides a route to trans-fused octalinones bearing angular methyl groups with functionality corresponding to that which would have been possible from a trans-directed Diels-Alder reaction.