Measurement and Modeling Solubility of Bioactive Coumarin and its Derivatives in Supercritical Carbon Dioxide

Yoo KP; Shin HY; Noh MJ; You SS

Korean Journal of Chemical Engineering, Vol.14, No.5, 341-346, September, 1997

To design a supercritical fluid extraction process for the separation of bioactive substances from natural products, a quantitative knowledge of phase equilibria between target biosolutes and solvent is necessary. However, mostly no such information is available in literature to date. Thus in the present study, illustratively the solubility of bioactive coumarin and its various derivatives (i.e., hydroxy-, methyl-, and methoxy-derivatives) in supercritical CO2 were measured at 308.15-328.15K and 10-30 MPa. Also, the pure physical properties such as normal boiling point, critical constants, acentric factor, molar volume and standard vapor pressure for coumarin and its derivatives were estimated. By these estimated information, the measured solubilities were quantitatively correlated by an approximate lattice equation of state proposed recently by the present authors.

Keywords:Measurement;Thermodynamic Modeling;Solubility;Supercritical Carbon Dioxide;Coumarin Derivatives

[References]

Bevan CD, Marshall PS, Nat. Prod. Rep., 11, 451 (1994)
Choi YH, Kim J, Noh MJ, Park EM, Yoo KP, Korean J. Chem. Eng., 13(2), 216 (1996)
Joo SJ, Choi YH, Kim J, Noh MJ, Park EM, Yoo KP, "Supercritical Carbon Dioxide Extractionof Pharmaceutical Agents from Plant Materials in Korea," Proc. 3rd Int. Symp. Supercrit. Fluids, Strasbourg, France, 2, 407 (1994)
King MB, Bott TR, "Extraction of Natural Products Using Near-Critical Solvents," Chapman & Hall, London (1993)
Lee CS, Yoo KP, "Lattice-hole Based Equations of State and Their Applications to Complex Fluids," Proc. Int. Symp. on Molec. Thermo. & Molec. Simul., Hosei Univ., Tokyo, Japan, 109, 53 (1997)
Liu B, Lockwood B, Gifford LA, J. Chromatogr., 690, 250 (1995)
Lyman WJ, Reehl WF, Rosenblattt DH, "Handbook of Chemical Property Estimation Methods," ACS Press, Washington, D.C., Ch. 12 (1990)
Ma X, Yu X, Zhang Z, Mao J, Chromatographia, 32, 40 (1991)
Modey WK, Mulholland DA, Raynor MW, Phytochem. Anal., 4, 1 (1996)
Noh MJ, Choi ES, Yoo KP, Choi YH, Yeo H, Lee J, Park EJ, Kim J, Park HK, Kim KH, Chem. Ind. Technol., 15(1), 14 (1997)
Noh MJ, Choi ES, Kim SH, Yoo KP, Choi YH, Chin YW, Kim J, Korean J. Chem. Eng., 14(2), 109 (1997)
Reid RC, Prausnitz JM, Poling BE, "The Properties of Gases and Liquids," 4th ed., McGraw-Hill Book Co., Ch. 3 & 7 (1987)
Rizvi SSH, "Supercritical Fluid Processing of Food and Biomaterials," Blackie Academic and Professional Co., London (1994)
Smith RM, Burford MD, J. Chromatogr., 627, 255 (1991)

[Referenced By]

[1] Bevan CD, Marshall PS, Nat. Prod. Rep., 11, 451 (1994)

[2] Choi YH, Kim J, Noh MJ, Park EM, Yoo KP, Korean J. Chem. Eng., 13(2), 216 (1996)

[3] Joo SJ, Choi YH, Kim J, Noh MJ, Park EM, Yoo KP, "Supercritical Carbon Dioxide Extractionof Pharmaceutical Agents from Plant Materials in Korea," Proc. 3rd Int. Symp. Supercrit. Fluids, Strasbourg, France, 2, 407 (1994)

[4] King MB, Bott TR, "Extraction of Natural Products Using Near-Critical Solvents," Chapman & Hall, London (1993)

[5] Lee CS, Yoo KP, "Lattice-hole Based Equations of State and Their Applications to Complex Fluids," Proc. Int. Symp. on Molec. Thermo. & Molec. Simul., Hosei Univ., Tokyo, Japan, 109, 53 (1997)

[6] Liu B, Lockwood B, Gifford LA, J. Chromatogr., 690, 250 (1995)

[7] Lyman WJ, Reehl WF, Rosenblattt DH, "Handbook of Chemical Property Estimation Methods," ACS Press, Washington, D.C., Ch. 12 (1990)

[8] Ma X, Yu X, Zhang Z, Mao J, Chromatographia, 32, 40 (1991)

[9] Modey WK, Mulholland DA, Raynor MW, Phytochem. Anal., 4, 1 (1996)

[10] Noh MJ, Choi ES, Yoo KP, Choi YH, Yeo H, Lee J, Park EJ, Kim J, Park HK, Kim KH, Chem. Ind. Technol., 15(1), 14 (1997)

[11] Noh MJ, Choi ES, Kim SH, Yoo KP, Choi YH, Chin YW, Kim J, Korean J. Chem. Eng., 14(2), 109 (1997)

[12] Reid RC, Prausnitz JM, Poling BE, "The Properties of Gases and Liquids," 4th ed., McGraw-Hill Book Co., Ch. 3 & 7 (1987)

[13] Rizvi SSH, "Supercritical Fluid Processing of Food and Biomaterials," Blackie Academic and Professional Co., London (1994)

[14] Smith RM, Burford MD, J. Chromatogr., 627, 255 (1991)