Journal of the American Chemical Society, Vol.132, No.48, 17068-17070, 2010
Cooperative Melting in Caged Dimers with Only Two DNA Duplexes
Small molecule DNA hybrids with only two parallel DNA duplexes (rSMDH(2)) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.