화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.133, No.6, 1781-1783, 2011
Aza-Oxy-Carbanion Relay via Non-Brook Rearrangement: Efficient Synthesis of Furo[3,2-c]pyridinones
An aza-oxy-carbanion relay via tandem Michael addition/ring opening of cyclopropane and recyclization/carbanion migration/electrophile trapping has been developed by the utilization of 1-cinnamoylcyclopro-panecarboxamides to react with various electrophiles. This represents the first example of anion relay chemistry via non-Brook rearrangement. This novel protocol has been applied in the facile and efficient synthesis of biologically active bicyclic furo[3,2-c]pyridinone compounds.