Eudragit L100/cellulose acetate butyrate blend microspheres were prepared by solvent evaporation technique using poly(vinyl alcohol) as an emulsifying agent nifedipine (NFD) was successfully loaded into these microspheres. The effect of experimental variables such as ratio of blend ratio on NFD encapsulation efficiency, release rate, size, and morphology of the microspheres has been investigated. Scanning electron micrographs indicated the formation of spherical microspheres. Mean particle size of the microspheres has been measured by the laser light scattering technique ranged between 100 and 120 mu m. NFD was successfully encapsulated up to 80% in the polymeric matrices. In vitro dissolution experiments performed in pH 7.4 buffer medium indicated a controlled release of NFD from the blend microspheres up to 12 h.