A series of benchmark experiments on the effect of the wetting state on the flow properties in porous media were performed, allowing us to relate the wetting properties at the pore scale to the macroscale hydrodynamics. Drainage of n-alkanes (oils) displaced by air in a model porous medium consisting of water-wet sand was studied using gamma-ray densitometry and weight measurements. The enormous advantage of our system is that we know and control the wetting properties perfectly: we can tune the wetting properties by changing the salinity of the water. This allows us to perform porous medium flow experiments for the different wetting states without changing the transport properties (viscosity and density) of the oil. Drainage is found to be more efficient, and consequently oil recovery more important for partial wetting.