록소프로펜 라세미체 분리를 위한 유사이동층 크로마토그래피의 전산모사

김인호; 송성문; In Ho Kim; Sung Moon Song

Korean Chemical Engineering Research, Vol.49, No.5, 623-627, October, 2011

Export Citation

록소프로펜 라세미체 분리를 위한 유사이동층 크로마토그래피의 전산모사

Simulated Moving Bed(SMB) Chromatography Simulation for Loxoprofen Racemates Separation

김인호 ^†, 송성문

충남대학교 화학공학과, 305-764 대전시 유성구 궁동 220

In Ho Kim^†, and Sung Moon Song

Department of Chemical Engineering, Chungnam National University, 220 Gung-dong, Yuseong-gu, Daejeon 305-764, Korea

E-mail:

초록

Loxoprofen racemate를 분리하기 위해 SMB에서 운전조건을 탐색하였다. Aspen simulator를 이용하여 전산모사를 함으로써 loxoprofen racemate를 분리할 수 있는 운전조건을 다음과 같이 제시할 수 있었다. Raffinate 순도를 증가시키기 위해 삼각도에서 왼쪽 중간 부분의 m2, m3 좌표를 정하여야 하며 내부농도 분포도에서 raffinate와 extract 분포곡선을 겹치지 않도록 하여야 한다.

Simulated moving bed(SMB) chromatography was simulated for separating loxoprofen racemates. Aspen chromatography simulator was utilized with Henry’s constants of loxoprofen racemates which were obtained by batch chromatography experiments. Raffinate stream concentrations as well as purities were calculated with various m2 and m3 values in the triangle diagram obtained from two Henry’s constants 7.9 and 10.1. Purity values are high under the conditions that the m2-m3 coordinates are near the left central region in the diagram and feed flow rates are lower. Concentration profiles of raffinate and extract streams along SMB columns explain the purity change in the case of increasing the column numbers installed at SMB.

Keywords:Simulated Moving Bed(SMB);Simulation;Loxoprofen Racemates

[References]

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Heuer C, Hugo P, Mann G, Seidal-Morgenstern A, J. Cromatogr. A., 752, 19 (1996)
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Juza M, J. Chromatogr. A., 895, 35 (1999)
Yoon TH, Lee E, Kim JM, Kim WS, Kim IH, Korean J. Chem. Eng., 25(2), 285 (2008)

[Related Articles]

[1] Pirkle WH, Pochapsky TC, “Advances in Chromatography," Giddings JC, Ed., Marcel Dekker, New York, 27, Chap. 3 (1987)

[2] Heuer C, Hugo P, Mann G, Seidal-Morgenstern A, J. Cromatogr. A., 752, 19 (1996)

[3] Nagawa M, Shoji F, J.Cromatogr. A., 877, 113 (1992)

[4] Ching CB, Lim BG, Lee EJD, Ng SC, J.Cromatogr. A., 634, 215 (1993)

[5] Nicoud RM, Fuchs G, Adam P, Bailly M, Kusters E, Antia FD, Reuille R, Schmid E, Chirality., 5, 257 (1993)

[6] Sugimoto M, Kojima T, Asami M, Iizuka Y, Matsuda K, Biochem. Pharmacol., 42, 2363 (1991)

[7] Terada A, Naruto S, Wachi K, Tanaka S, Iizuka Y, Misaka E, J. Med. Chem., 27, 212 (1984)

[8] Guiochon G, Golshan-Shirazi S, Katti A, Fundamentals of Preparative and Nonlinear Chromatography. Academic Press (1994)

[9] Storti G, Mazzotti M, Morbidelli M, Carra S, AIChE J., 39, 471 (1993)

[10] Juza M, J. Chromatogr. A., 895, 35 (1999)

[11] Yoon TH, Lee E, Kim JM, Kim WS, Kim IH, Korean J. Chem. Eng., 25(2), 285 (2008)