Polymeric Nanofiber Coated Esophageal Stent for Sustained Delivery of an Anticancer Drug

Chun Gwon Park; Myung Hun Kim; Min Park; Ji Eun Lee; Seung Ho Lee; Jung-Hwan Park; Kyung-Hwan Yoon; Young Bin Choy

Macromolecular Research, Vol.19, No.11, 1210-1216, November, 2011

DOI10.1007/s13233-011-1112-5 Export Citation

Polymeric Nanofiber Coated Esophageal Stent for Sustained Delivery of an Anticancer Drug

Chun Gwon Park¹, Myung Hun Kim¹, Min Park¹, Ji Eun Lee¹, Seung Ho Lee¹, Jung-Hwan Park², Kyung-Hwan Yoon³, and Young Bin Choy^{1, 4, †}

¹Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, 152-742, Korea
²College of BioNano Technology and Gachon Research Institute, Kyungwon University, Gyeonggi, 461-701, Korea
³Department of Chemistry, Seoul National University, Seoul, 151-747, Korea
⁴Department of Biomedical Engineering, College of Medicine and Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, 110-799, Korea

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In this study, we developed an esophageal stent capable of sustained delivery of an anticancer drug, fluorouracil (5-FU). The stents were coated with drug-loaded poly(lactic-co-glycolic acid) (PLGA) nanofibers (DPN) via the electrospinning method, which exhibited a sustained drug release for up to 6 days. To prolong drug release, we also added the nanofiber layers composed of PLGA alone (PN), surrounding the DPN layer, as a more resistive diffusion barrier, where a period of drug release could be extended to 21 days with the DPN layer topped with another 192 μm thick PN layer. Therefore, we envisioned longer period of drug release with the thicker PN layers, obtained simply with a longer collection time of PLGA nanofibers via electrospinning. Overall, we concluded that the drug-delivery esophageal stent prepared in this study is promising in the long-term treatment of dysphagia caused by esophageal cancer.

Keywords:drug delivery systems;electrospinning;esophageal stents;fluorouracil;poly(lactic-co-glycolic acid).

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[2] Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun M, CA Cancer J. Clin., 59, 225 (2009)

[3] Muller J, Erasmi H, Stelzner M, Zieren U, Pichlmaier H, Br. J. Surg., 77, 845 (1990)

[4] Enzinger P, Mayer R, N. Engl. J. Med., 349, 2241 (2003)

[5] Sundelof M, Ringby D, Stockeld D, Granstrom L, Jonas E, Freedman J, Scand. J. Gastroenterol., 42, 11 (2007)

[6] Xinopoulos D, Bassioukas S, Dimitroulopoulos D, Korkolis D, Steinhauer G, Kipraios D, Paraskevas E, Dis. Esophagus, 22, 354 (2009)

[7] Ellul J, Watkinson A, Khan R, Adam A, Mason R, Br. J. Surg., 82, 1678 (1995)

[8] Eberhart RC, Su SH, Nguyen KT, Zilberman M, Tang L, Nelson KD, Frenkel P, J. Biomater. Sci.-Polym. Ed., 14, 299 (2003)

[9] Tung R, Kaul S, Diamond GA, Shah PK, Ann. Intern. Med., 144, 913 (2006)

[10] Nakazawa G, Finn AV, Kolodgie FD, Virmani R, Expert. Rev. Med. Devices, 6, 33 (2009)

[11] Jeon S, Eun S, Shim C, Ryu C, Kim J, Cho J, Lee J, Lee M, Jin S, Endoscopy, 41, 449 (2009)

[12] Guo Q, Guo S, Wang Z, J. Control. Release, 118, 318 (2007)

[13] Guo SR, Wang ZM, Zhang YQ, Lei L, Shi JM, Chen KM, Yu Z, J. Pharm. Sci., 99, 3009 (2010)

[14] Kuraishi K, Iwata H, Nakano S, Kubota S, Tonami H, Toda M, Toma N, Matsushima S, Hamada K, Ogawa S, J. Biomed. Mater. Res. Part B: Appl. Biomater., 88, 230 (2009)

[15] Puskas JE, Munoz-Robledo LG, Hoerr RA, Foley J, Schmidt SP, Evancho-Chapman M, Dong J, Frethem C, Haugstad G, Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 1, 451 (2009)

[16] Longley D, Harkin D, Johnston P, Nat. Rev. Cancer, 3, 330 (2003)

[17] Wu XS, in Encyclopedic handbook of biomaterials and bioengineering, Marcel Dekker, New York, 1995, Vol. 1, p 1015.

[18] Huang ZM, Zhang YZ, Kotaki M, Ramakrishna S, Compos. Sci. Technol., 63, 2223 (2003)

[19] Vasita R, Shanmugam K, Katti DS, Polym. Degrad. Stabil., 95, 1605 (2010)

[20] Lee JS, Chae GS, An TK, Khang G, Cho SH, Lee HB, Macromol. Res., 11(3), 183 (2003)

[21] Shim C, Cho Y, Moon J, Kim J, Cho J, Kim Y, Lee J, Lee M, Endoscopy, 33, 843 (2001)

[22] Berkland C, Pack DW, Kim K, Biomaterials, 25, 5649 (2004)

[23] Dillen K, Vandervoort J, Van den Mooter G, Verheyden L, Ludwig A, Int. J. Pharm., 275, 171 (2004)

[24] Zong X, Kim K, Fang D, Ran S, Hsiao BS, Chu B, Polymer, 43, 4404 (2002)

[25] Wilkes CE, Summers JW, Daniels CA, Berard MT, PVC handbook, Hanser Gardner Publications, Cincinnati, 2005.

[26] Washington N, Washington C, Wilson C, Physiological pharmaceutics: barriers to drug absorption, CRC Press, Boca Raton, 2001.

[27] Gennaro AR, Osol A, Remington’s Pharmaceutical Sciences, Mack Publishing Company, Pennsylvania, 1975.

[28] Verschuur EML, Repici A, Kuipers EJ, Steyerberg EW, Siersema PD, Am. J. Gastroenterol., 103, 304 (2008)

[29] Fang J, Niu HT, Lin T, Wang XG, Chin. Sci. Bull., 53, 2265 (2008)

[30] Jayakumar R, Prabaharan M, Nair S, Tamura H, Biotechnol. Adv., 28, 142 (2010)

[31] Zhu KJ, Zhang JX, Wang C, Yasuda H, Ichimaru A, Yamamoto K, J. Microencapsul., 20(6), 731 (2003)

[32] Xie ZW, Buschle-Diller G, J. Appl. Polym. Sci., 115(1), 1 (2010)