Increase of degradation and water uptake rate using electrospun star-shaped poly(D,L-lactide) nanofiber

Eun Jung Choi; Bokgi Son; Taek Sung Hwang; Eui-Hwan Hwang

Journal of Industrial and Engineering Chemistry, Vol.17, No.4, 691-695, July, 2011

DOI10.1016/j.jiec.2010.10.024 Export Citation

Increase of degradation and water uptake rate using electrospun star-shaped poly(D,L-lactide) nanofiber

Eun Jung Choi, Bokgi Son, Taek Sung Hwang^†, and Eui-Hwan Hwang^{1, †}

Department of Chemical Engineering, College of Engineering, Chungnam National University, 79 Daehangno, Yuseong-gu, Daejeon 305-764, Republic of Korea
¹Department of Chemical Engineering, Kongju National University, 275 Budae-dong, Seobuk-gu, Cheonan, Chungnam 331-717, Republic of Korea

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Conventional poly(D,L-lactide) (PLA)-based scaffolds have limited in biomedical applications because they inherently have long degradation time, strong stiffness, and hydrophobicity. This study presents a novel approach for solving the technical issues using electrospun nanofiber of star-shaped PLA. The nanofibers can be substantially altered by the control of number arms in monomer unit. The electrospun scaffolds based on the star-shaped PLA polymers, comprised of randomly interconnected webs of submicron sized fibers. In this study, the effects of PLA polymers with different branched arms on the rate of water uptake and biodegradation of electrospun scaffolds are investigated. The hydrophilicity of electrospun PLA nanofibers, as determined by rate of water uptake, is dramatically increased. In addition, in vitro degradation study clearly confirms that the electrospun nanofiber having 3-branched arms shows the 75% weight loss in 3 days, which suggest that the electrospun nanofiber with 3 armsmonomer is most easily degradable one. The selection of branched PLA combined with the non-invasive electrospinning process is useful in the synthesis of a novel kind of biodegradable scaffolds suitable for different biomedical applications because of easy control of porosity, mechanical flexibility, higher water uptake, and biodegradability.

Keywords:Poly(lactide) (PLA);Biodegradation;Hydrophilicity;Electrospinning;Nanofiber

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[1] Yang F, Murugan R, Ramakrishna S, Wang X, Mac YX, Wang S, Biomaterials., 25, 1891 (2004)

[2] Schmidt CE, Leach JB, Annu. Rev. Biomed. Eng., 5, 293 (2003)

[3] Bellamkonda R, Aebischer P, Biotechnol. Bioeng., 43(7), 543 (1994)

[4] Jang WY, Shin BY, Lee TJ, Narayan R, J. Ind. Eng. Chem., 13(3), 457 (2007)

[5] Xu CY, Inai R, Kotaki M, Ramakrishna S, Biomaterials., 25, 877 (2004)

[6] Kwak H, Bae SY, J. Ind. Eng. Chem., 12(3), 387 (2006)

[7] Chang JH, Shim CH, Kim KJ, Bae BS, J. Ind. Eng. Chem., 11(3), 471 (2005)

[8] Ma Z, Kotaki M, Inai R, Ramakrishna S, Tissue Eng., 11, 101 (2005)

[9] Ciardelli G, Chiono V, Vozzi G, Pracella M, Ahluwalia A, Barbani N, Cristallini C, Giusti P, Biomacromolecules, 6(4), 1961 (2005)

[10] Koh HS, Yong T, Chan CK, Ramakrishna S, Biomaterials., 29, 3574 (2008)

[11] Cheng M, Deng J, Yang F, Gong Y, Zhao N, Zhang X, Biomaterials., 24, 2871 (2003)

[12] Chong EJ, Phan TT, Lim IJ, Zhang YZ, Bay BH, Ramakrishna S, Lim CT, Acta Biomater., 3, 321 (2007)

[13] Schnell E, Klinkhammer K, Balzer S, Brook G, Kleeb D, Dalton P, Mey J, Biomaterials., 28, 3012 (2007)

[14] Doshi J, Reneker DH, J. Electrostat., 35, 151 (1995)

[15] Buchko CJ, Chen LC, Shen Y, Martin DC, Polymer, 40(26), 7397 (1999)

[16] Reneker DH, Chun I, Nanotechnology., 7, 216 (1996)

[17] Hiltunen K, Harkonen M, Seppala JV, Vaananen T, Macromolecules, 29(27), 8677 (1996)

[18] Chen CC, Chueh JY, Tseng H, Huang HH, Lee SY, Biomaterials., 24, 1167 (2003)

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[20] Kricheldorf HR, Berl M, Scharnagl N, Macromolecules., 21, 286 (1988)

[21] Huntmacher DW, Biomaterials., 21, 2529 (2000)

[22] Kim SH, Kim YH, Polym. Sci. Technol., 16, 468 (2005)