The hydrodynamic behavior of a two impinging streams cyclone reactor (TISCR) was simulated using the computational fluid dynamics (CFD) technique. An Eulerian multiphase model has been used to compute the unsteady flow of a solid-liquid suspension in a 3D geometric configuration. The mean residence time (t(m)) and holdup of solid particles were calculated from a number of simulated results obtained at different solid and liquid flow rates. The CFD simulation results were compared with the experimental data available in the literature and a fairly well agreement was observed. Such a correlation was gradually improved with increasing solid flow rate. (C) 2010 Elsevier B.V. All rights reserved.