A simulation of the anaerobic process of a biogas production for different substrates was realized. The simulation was based on the Anaerobic Digestion Model No. 1 (ADM1). The experimental work comprehends batch-experiments and experiments in a continuous stirred-tank reactor at lab scale with different substrates used in a biogas production. The comparison between the experiments and the simulations of the process leads to a modification in ADM1. Furthermore a classification of substrates was developed according to their biodegradability to meet the fractions of the ADM1 simulation. The simulations for the different substrates showed a satisfactory agreement with the measured values.