Cationic water soluble cyclophane bearing a pyrene 1 was synthesize as a host for inclusion of anionic guest molecules Cationic host 1 was found to be incorporated into human hepatoblastome HepG2 cells effectively Moreover, 8-anilinonaphthalene 1-sulfonate (ANS) having an Inherent poor cell permeability was taken up into the cells in the presence of 1 through formation of host-guest complexes