The relationship between synthesis conditions of iron-containing mesoporous silica (Fe-MCM-41) and UV-visible absorbance was studied. Fe-MCM-41 with high UV absorption and low visible absorption was effectively synthesized by using [Fe(acac)3] as an iron source and employing calcination for the template removal. The obtained Fe-MCM-41 did not exhibit photocatalytic activity as determined by dye decomposition, and its SPF and PA values were at an acceptable level, concluding that there is a possibility as a new sunscreen agent.