Chemistry Letters, Vol.40, No.10, 1176-1178, 2011
Axial-selectivity in Prins Cyclization Reaction: Synthesis of 4-Iodotetrahydropyrans
Trimethylsilyl triflate and tetrabutylammonium iodide (TBAI) effectively mediate the Prins cyclization of homoallylic alcohols and aldehydes to give 4-iodotetrahydropyrans with axial selectivity and good yields.