Numerical simulation of the vaporization of multi-component liquid fuels under high-pressure conditions is conducted in this study. A high-pressure drop vaporization model is developed by considering the high-pressure phase equilibrium which equates the fugacity of each component in both liquid and vapor phases. Peng-Robinson equation of state is used for the calculation of fugacity. To model the vaporization of diesel fuel under high-pressure conditions, continuous thermodynamics based on a gamma distribution is coupled with phase equilibrium by correlating the parameters of the equation of state with the molecular weights of the continuous components. The high-pressure vaporization model is validated using the experimental data of n-heptane drops under different ambient pressures and temperatures. Good levels of agreement are obtained in drop size history. Predicted results of the vaporization of diesel fuel drops show that increasing ambient pressure leads to a shorter drop lifetime under high temperature conditions (e.g., 900 K). On the other hand, at a slightly lower temperature of 700K, the drop lifetime increases as the ambient pressure increases. It is found that the net affects of high ambient pressure on drop vaporization are determined by two competing factors, namely, reduced mass transfer number and reduced enthalpy of vaporization. The model was further applied to biodiesel and its blends with diesel fuel. The fuel blend is modeled based on a method that continuous thermodynamics is used to model diesel fuel and biodiesel is modeled as a mixture of its five representative components. Results of single drop vaporization history show that drop lifetime increases as the volume fraction of biodiesel in the fuel blend increases. This phenomenon reveals the low vaporization rate of biodiesel that has a higher critical temperature than diesel fuel. It is also observed that the volume fraction of biodiesel in the fuel blend increases during vaporization and its vapor concentrates near the tip of the liquid spray while diesel fuel vapor is around the entire liquid spray. (C) 2011 The Combustion Institute. Published by Elsevier Inc. All rights reserved.