Combustion in a furnace equipped with two HiTAC burner pairs, with a thermal power of 100kW(th) each, has been investigated experimentally and computationally. The objective of this study is (1) to observe differences in the performance of the furnace operating in two different firing modes, parallel and staggered, and (2) to explain these differences using detailed CFD simulations. Besides the permanent measurements of temperature, flow and pressure, in-furnace probe measurements of temperature, oxygen and emissions (NO and CO) have been performed. Experimental results show that the efficiency of the furnace was higher in parallel mode compared to staggered mode, 48% and 41% respectively. The values of CO emitted were equal for both firing modes. However, in parallel mode the NOx production was 39 ppm(v)@3%O-2, whereas in staggered mode 53 ppm(v)@3%O-2 NOx was produced. Considering both efficiency and emissions, parallel firing mode performs better than staggered mode. Next, CFD simulations of the furnace were performed in order to explain the observed differences. The simulations were validated with the in-furnace measurements. It was confirmed that the furnace firing in parallel mode achieved a higher efficiency. The radiative heat transfer was higher due to formation of a larger zone with gases with improved radiative properties. In addition, higher velocities along the cooling tubes, due to lower momentum destruction, led to higher convective heat transfer. Also, the lower production of NOx in parallel mode was reproduced by the simulations. This is due to the fact that in parallel mode the fuel jets are merging slower with the combustion air jet, leading to less intense combustion zones. Thus, lower peak temperatures and radical concentrations are achieved, and the NOx production via the thermal and N2O pathways was lower.