This paper reports the application of chitosan-Fe3O4 (CS-Fe3O4) nanocomposite modified glassy carbon electrodes for the amperometric determination of bisphenol A (BPA). We observed that the CS-Fe3O4 nanocomposite could remarkably enhance the current response and decrease its oxidation overpotential in the electrochemical detection. Experimental parameters, such as the amount of the CS-Fe3O4. the accumulation potential and time, the pH value of buffer solution etc. were optimized. Under the optimized conditions, the oxidation peak current was proportional to BPA concentration in the range between 5.0 x 10(-8) and 3.0 x 10(-5) mol dm(-3) with the correlation coefficient of 0.9992 and the limit of detection of 8.0 x 10(-9) mol dm(-3) (S/N = 3). The proposed sensors were successfully employed to determine BPA in real plastic products and the recoveries were between 92.0% and 06.2%. This strategy might open more opportunities for the electrochemical determination of BPA in practical applications. Additionally, the leaching studies of BPA on incubation time using the as-prepared modified electrode were successfully carried out. (C) 2011 Elsevier Ltd. All rights reserved.