Turbulent double-diffusive natural convection is of fundamental interest and practical importance. In the present work we investigate systematically the effects of thermal Rayleigh number (Ra), ratio of buoyancy forces (N) and aspect ratio (A) on entropy generation of turbulent double-diffusive natural convection in a rectangle cavity. Several conclusions are obtained: (1) The total entropy generation number (S-total) increases with Ra, and the relative total entropy generation rates are nearly insensitive to Ra when Ra <= 10(9); (2) Since N > 1, S-total increases quickly and linearly with N and the relative total entropy generation rate due to diffusive irreversibility becomes the dominant irreversibility; and (3) S-total increases nearly linearly with A. The relative total entropy generation rate due to diffusive and thermal irreversibilities both are monotonic decreasing functions against A while that due to viscous irreversibility is a monotonic increasing function with A. More important, through the present work we observe a new phenomenon named as "spatial self-copy" in such convectional flow. The "spatial self-copy" phenomenon implies that large-scale regular patterns may emerge through small-scale irregular and stochastic distributions. But it is still an open question required further investigation to reveal the physical meanings hidden behind it. (C) 2011 Elsevier Ltd. All rights reserved.