It is necessary to adopt appropriate control strategies to save energy and improve the indoor air quality (IAQ). On the validated TRNSYS simulation platform, four different control strategies are investigated to examine the indoor air temperature, energy consumption, CO2 concentration and predicted mean vote (PMV) for the variable air volume (VAV) systems in an office building in Shanghai. As an original scheme, Strategy A using constant outdoor air intake fraction shows high energy consumption, low CO2 concentration and acceptable thermal comfort. By using minimum outdoor air ventilation based on dynamic occupancy detection, Strategy B can provide more than 15% energy saving, acceptable PMV value but high CO2 concentration in breathing zone. By using indoor air temperature reset, Strategy C presents the most energy savings beyond 20% reduction, low CO2 concentration but poor thermal comfort. In mild seasons, combining enthalpy-based outdoor airflow economizer cycle with supply air temperature reset, Strategy D can achieve 9.4% energy savings and the lowest CO2 concentration. Taken together, each strategy covers some strengths as well as some weaknesses. How to comprehensively assess a control strategy for all specific objectives should be considered in future studies. (C) 2010 Elsevier B.V. All rights reserved.