화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.20, No.3, 234-243, March, 2012
DOI10.1007/s13233-012-0049-7  Export Citation
In vitro Degradation and Protein Release of Transparent and Opaque Physical Hydrogels of Block Copolymers at Body Temperature
Lin Yu1, 2, Zheng Zhang1, 3, and Jiandong Ding1, 2, †
  • 1State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai, 200433, P. R. China
  • 2Key Laboratory of Smart Drug Delivery of Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China
  • 3, China
E-mail:
Poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEGPLGA) triblock copolymers were synthesized at 130 and 160 ℃. The concentrated aqueous solutions of both specimens underwent reversible sol-to-(transparent gel)-to-(opaque gel) transitions upon heating but exhibited different critical gelation concentrations and transition temperatures, possibly due to the minor sequence differences between D,L-lactide (LA) and glycolide (GA) in the PLGA blocks. Aqueous solutions (20 wt%) of the copolymers synthesized at 130 and 160 ℃ spontaneously formed an opaque gel and a transparent gel at body temperature, respectively. The resulting hydrogels displayed similar in vitro degradation profiles in phosphate buffer saline solutions at 37 ℃. Nevertheless, the late-stage releases of bovine serum albumin from the physical hydrogels differed. The present study reveals for the first time that transparent vs. opaque thermogel state influences some of their biomaterialrelated properties via the “overheat degree” of the thermogelling systems at a given working temperature, usually 37 ℃.
Keywords:transparent gel;opaque gel;degradation;protein release;sol-gel transition;polymerization temperature.
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