Polysuccinimide Graft Copolymer Nano Aggregates Encapsulating Magnetites for Imaging Probe

Hyunjung Kim; Dukjoon Kim

Macromolecular Research, Vol.20, No.3, 259-265, March, 2012

DOI10.1007/s13233-012-0052-z Export Citation

Polysuccinimide Graft Copolymer Nano Aggregates Encapsulating Magnetites for Imaging Probe

Hyunjung Kim, and Dukjoon Kim^†

School of Chemical Engineering, Theranostic Macromolecules Research Center, Sungkyunkwan University, Gyeonggi, 440-746, Korea

E-mail:

Polysuccinimide (PSI) grafted with methylpoly(ethylene glycol) (MPEG) was synthesized and employed to encapsulate pre-synthesized magnetite using a co-precipitation method. This encapsulation was stabilized by the chemical bonding between PSI and magnetite via the introduction of a bridging compound, 3-aminopropylethoxysilane (APS). The morphology and properties of the magnetite-encapsulated polymer particles were widely characterized to investigate their applications as potential magnetic resonance (MR) imaging probes. The Fourier transform infrared and Fourier transform nuclear magnetic resonance spectroscopy confirmed the successful synthesis of the MPEG-g-PSI- and APS-coated magnetites in addition to X-ray diffraction of their crystalline structure. The size and distribution of the pure and polymer-coated magnetite aggregates were examined using transmission electron microscopy and light scattering analysis. The magnetite-encapsulated aggregates prepared in this study showed excellent superparamagnetic and biocompatible properties that enabled their successful use as MR imaging probes

Keywords:nano aggregate;encapsulation;magnetite;polysuccinimide;imaging probe.

[References]

Horak D, Rittich B, Spanova A, Benes MJ, Polymer, 46(4), 1245 (2005)
Ma M, Zhang MY, Yu W, Shen H, Zhang H, Gu N, Colloids Surf. A: Physicochem. Eng. Asp., 212, 219 (2003)
Brown MA, Semelka RC, MRI: Basic Principles and Applications, 3rd ed., John Wiley & Sons, New Jersey, 2003, Chapter 16.
Simberg D, Duja T, Park JH, Essler M, Pilch J, Zhang L, Proc. Natl. Acad. Sci. U.S.A., 104, 932 (2007)
Lee SM, Kim SJ, Guo H, Kang IK, Biomater. Res., 12, 19 (2008)
Han L, Li S, Yang Y, Zhao F, Huang J, Chang J, J.Magn. Magn. Mater., 313, 236 (2007)
Yang J, Lee J, Kang J, Lee K, Suk JS, Yoon HG, Huh YM, Ham S, Langmuir., 24, 3147 (2008)
Lee H, Lee E, Kim DK, Jang NK, Jeong YY, Jon S, J. Am. Chem. Soc., 128(22), 7383 (2006)
Gupta AK, Gupta M, Biomaterials., 26, 1565 (2005)
Lee H, Yu MK, Park S, Moon S, Min JJ, Jeong YY, Kang HW, Jon S, J. Am. Chem. Soc., 129(42), 12739 (2007)
Huh YM, Jun YW, Song HT, Kim S, Choi JS, Lee JH, Yoon S, Kim KS, Shin JS, Suh JS, Cheon J, J. Am. Chem. Soc., 127(35), 12387 (2005)
Heinze T, Liebert T, Heublein B, Hornig S, Adv. Polym.Sci., 205, 199 (2006)
Xia Z, Wang G, Tao K, Li J, J. Magn. Magn. Mater., 293, 182 (2005)
Gupta AK, Gupta M, Biomaterials., 26, 3995 (2005)
Laurent S, Forge D, Port M, Roch A, Robic C, Elst LV, Muller RN, Chem. Rev., 108(6), 2064 (2008)
Park BJ, Fang FF, Zhang K, Choi HJ, Korean J. Chem. Eng., 27(2), 716 (2010)
Seo K, Kim D, Macromol. Biosci., 6, 758 (2006)
Neri P, Antoni G, Benvenuti F, Colola F, Gazzei G, J.Med. Chem., 16, 893 (1972)

[Referenced By]

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[1] Horak D, Rittich B, Spanova A, Benes MJ, Polymer, 46(4), 1245 (2005)

[2] Ma M, Zhang MY, Yu W, Shen H, Zhang H, Gu N, Colloids Surf. A: Physicochem. Eng. Asp., 212, 219 (2003)

[3] Brown MA, Semelka RC, MRI: Basic Principles and Applications, 3rd ed., John Wiley & Sons, New Jersey, 2003, Chapter 16.

[4] Simberg D, Duja T, Park JH, Essler M, Pilch J, Zhang L, Proc. Natl. Acad. Sci. U.S.A., 104, 932 (2007)

[5] Lee SM, Kim SJ, Guo H, Kang IK, Biomater. Res., 12, 19 (2008)

[6] Han L, Li S, Yang Y, Zhao F, Huang J, Chang J, J.Magn. Magn. Mater., 313, 236 (2007)

[7] Yang J, Lee J, Kang J, Lee K, Suk JS, Yoon HG, Huh YM, Ham S, Langmuir., 24, 3147 (2008)

[8] Lee H, Lee E, Kim DK, Jang NK, Jeong YY, Jon S, J. Am. Chem. Soc., 128(22), 7383 (2006)

[9] Gupta AK, Gupta M, Biomaterials., 26, 1565 (2005)

[10] Lee H, Yu MK, Park S, Moon S, Min JJ, Jeong YY, Kang HW, Jon S, J. Am. Chem. Soc., 129(42), 12739 (2007)

[11] Huh YM, Jun YW, Song HT, Kim S, Choi JS, Lee JH, Yoon S, Kim KS, Shin JS, Suh JS, Cheon J, J. Am. Chem. Soc., 127(35), 12387 (2005)

[12] Heinze T, Liebert T, Heublein B, Hornig S, Adv. Polym.Sci., 205, 199 (2006)

[13] Xia Z, Wang G, Tao K, Li J, J. Magn. Magn. Mater., 293, 182 (2005)

[14] Gupta AK, Gupta M, Biomaterials., 26, 3995 (2005)

[15] Laurent S, Forge D, Port M, Roch A, Robic C, Elst LV, Muller RN, Chem. Rev., 108(6), 2064 (2008)

[16] Park BJ, Fang FF, Zhang K, Choi HJ, Korean J. Chem. Eng., 27(2), 716 (2010)

[17] Seo K, Kim D, Macromol. Biosci., 6, 758 (2006)

[18] Neri P, Antoni G, Benvenuti F, Colola F, Gazzei G, J.Med. Chem., 16, 893 (1972)