Multi-Core Vesicle Nanoparticles for Controlled Delivery of Protein Drug

Soon Hong Yuk; Keun Sang Oh; Seung Ki Kim; Jin Ho Lee; Sun Hang Cho; Kwangmeyung Kim; Hyesung Jeon; Ick Chan Kwon

Macromolecular Research, Vol.20, No.3, 309-312, March, 2012

DOI10.1007/s13233-012-0053-y Export Citation

Multi-Core Vesicle Nanoparticles for Controlled Delivery of Protein Drug

Soon Hong Yuk^†, Keun Sang Oh¹, Seung Ki Kim², Jin Ho Lee², Sun Hang Cho³, Kwangmeyung Kim¹, Hyesung Jeon¹, and Ick Chan Kwon¹

College of Pharmacy, Korea University, Chungnam, 339-700, Korea
¹Biomedical Research Center, Korea Institute of Science and Technology, Seoul, 136-791, Korea
²Department of Advanced Materials, Hannam University, Daejeon, 305-811, Korea
³Nanobiomaterials Laboratories, Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea

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The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.

Keywords:human growth hormone;Pluronic/PEG composite NPs;multi-core vesicle NPs;peptide drug;sustained release.

[References]

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Prokop A, Kozlov E, Carlesso G, Davidson JM, Adv.Polym. Sci., 160, 119 (2002)
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Lee KY, Yuk SH, Prog. Polym. Sci., 32, 669 (2007)
Oh KS, Han SK, Lee HS, Koo HM, Kim RS, Lee KE, Han SS, Cho SH, Yuk SH, Biomacromolecules, 7(8), 2362 (2006)
Jain RA, Biomaterials., 21, 2475 (2000)
Diwan M, Park TG, J. Control. Release., 73, 233 (2001)
Liu JW, Jiang XM, Ashley C, Brinker CJ, J. Am. Chem. Soc., 131(22), 7567 (2009)
Lei G, MacDonald RC, Biophys. J., 85, 1585 (2003)
Wang B, Zhang L, Bae SC, Granick S, Proc. Natl.Acad. Sci. U.S.A., 105, 18171 (2008)
Yuk SH, Oh KS, Koo H, Jeon H, Kim K, Kwon IC, Biomaterials., 32, 7924 (2011)
Jorgensen JO, Moller N, Lauritzen T, Christiansen JS, J. Clin. Endocrinol. Metab., 70, 1616 (1990)
Laursen T, Jorgensen JO, Christiansen JS, Endocrinol.Metab., 1, 33 (1994)
Laursen T, Jorgensen OL, Jakobsen G, Hansen BL, Christiansen JS, J. Clin. Endocrinol. Metab., 80, 2410 (1995)
Jostel A, Mukherjee A, Alenfall J, Smethurst L, Shalet SM, Clin. Endocrinol., 62, 623 (2005)
Vlugt-Wensink KD, de Vrueh R, Gresnigt MG, Hoogerbrugge CM, van Buul-Offers SC, de Leede LG, Sterkman LG, Crommelin DJ, Hennink WE, Verrijk R, Pharm. Res., 24, 2239 (2007)
Whitaker MJ, Ho J, Davies OR, Serhatkulu G, Stolnik-Trenkic S, Howdle SM, Skakesheff KM, J. Control.Release., 101, 85 (2005)
Davies OR, Lewis AL, Whitaker MJ, Tai H, Shakesheff KM, Howdle SM, Adv. Drug Deliv. Rev., 60, 373 (2008)
Jordan F, Naylor A, Kelly CA, Howdle SM, Lewis A, Illum L, J. Control. Release., 141, 153 (2010)
Messaoud T, Duplatre G, Waton G, Michels B, Phys.Chem. Chem. Phys., 7, 3839 (2005)
Nystrom B, Walderhaug H, J. Phys. Chem., 100(13), 5433 (1996)
Malmsten M, Lindman B, Macromolecules., 25, 5440 (1992)
Castellanos IJ, Crespo R, Griebenow K, J. Control.Release., 141, 135 (2003)

[Related Articles]

[1] Manning MC, Patel K, Borchardt T, Pharm. Res., 6, 903 (1989)

[2] Prokop A, Kozlov E, Carlesso G, Davidson JM, Adv.Polym. Sci., 160, 119 (2002)

[3] Tabata Y, Ikada Y, Adv. Drug Deliv. Rev., 31, 287 (1988)

[4] Lee KY, Yuk SH, Prog. Polym. Sci., 32, 669 (2007)

[5] Oh KS, Han SK, Lee HS, Koo HM, Kim RS, Lee KE, Han SS, Cho SH, Yuk SH, Biomacromolecules, 7(8), 2362 (2006)

[6] Jain RA, Biomaterials., 21, 2475 (2000)

[7] Diwan M, Park TG, J. Control. Release., 73, 233 (2001)

[8] Liu JW, Jiang XM, Ashley C, Brinker CJ, J. Am. Chem. Soc., 131(22), 7567 (2009)

[9] Lei G, MacDonald RC, Biophys. J., 85, 1585 (2003)

[10] Wang B, Zhang L, Bae SC, Granick S, Proc. Natl.Acad. Sci. U.S.A., 105, 18171 (2008)

[11] Yuk SH, Oh KS, Koo H, Jeon H, Kim K, Kwon IC, Biomaterials., 32, 7924 (2011)

[12] Jorgensen JO, Moller N, Lauritzen T, Christiansen JS, J. Clin. Endocrinol. Metab., 70, 1616 (1990)

[13] Laursen T, Jorgensen JO, Christiansen JS, Endocrinol.Metab., 1, 33 (1994)

[14] Laursen T, Jorgensen OL, Jakobsen G, Hansen BL, Christiansen JS, J. Clin. Endocrinol. Metab., 80, 2410 (1995)

[15] Jostel A, Mukherjee A, Alenfall J, Smethurst L, Shalet SM, Clin. Endocrinol., 62, 623 (2005)

[16] Vlugt-Wensink KD, de Vrueh R, Gresnigt MG, Hoogerbrugge CM, van Buul-Offers SC, de Leede LG, Sterkman LG, Crommelin DJ, Hennink WE, Verrijk R, Pharm. Res., 24, 2239 (2007)

[17] Whitaker MJ, Ho J, Davies OR, Serhatkulu G, Stolnik-Trenkic S, Howdle SM, Skakesheff KM, J. Control.Release., 101, 85 (2005)

[18] Davies OR, Lewis AL, Whitaker MJ, Tai H, Shakesheff KM, Howdle SM, Adv. Drug Deliv. Rev., 60, 373 (2008)

[19] Jordan F, Naylor A, Kelly CA, Howdle SM, Lewis A, Illum L, J. Control. Release., 141, 153 (2010)

[20] Messaoud T, Duplatre G, Waton G, Michels B, Phys.Chem. Chem. Phys., 7, 3839 (2005)

[21] Nystrom B, Walderhaug H, J. Phys. Chem., 100(13), 5433 (1996)

[22] Malmsten M, Lindman B, Macromolecules., 25, 5440 (1992)

[23] Castellanos IJ, Crespo R, Griebenow K, J. Control.Release., 141, 135 (2003)