A theoretical model of drug release in hydrogels was designed taking into account desorption processes on the solid phase surface and diffusion in pores. The model describes kinetics with two constant parameters independent of concentration and time: D-AB, the diffusion coefficient of component A in the liquid, and k, the transfer coefficient describing the rate of desorption of component A. The model was verified using experimental data concerning the release of bovine albumin from thermosensitive chitosan gels. The process of albumin release from hydrogels produced from chitosan glutamate can be described by parameters D-AB = 2.0 x 10(-9) m(2)/s and k = 1.02 x 10(-6) m/s. Calculations based on the model prove that it properly correlates experimental data.