A novel reactive sorption method has been devised for purification of curcuminoids from a complex multicomponent turmeric extract using a weakly basic polymer as a selective adsorbent. The experimental results are further supported by molecular simulation to quantify the specific interactions of curcumins with tertiary amine group of the adsorbent in the presence of organic solvents of different polarities. Both experimental data and theoretical calculations showed that methanol was the best solvent for adsorption, while acetone was useful for desorbing curcumins from the adsorbed state. Dynamic adsorption and particularly desorption operations showed a significant effect of intraparticle diffusivity limitations on the rate of adsorption and effective utilization of the adsorbent. However, increased temperature and exposure to ultrasound could increase desorption of curcumins from the column. Nearly 50% and 85% of curcuminoids are desorbed from the bed with acetone alone and with simultaneous exposure to ultrasound, respectively. After a single adsorption and desorption cycle, the purity of recovered curcuminoids increases to 98%. Individual components of the extract and the purified curcuminoid product were characterized by liquid chromatography-mass spectrometry.