A comprehensive three-dimensional numerical model is developed for simulation of the industrial opposed multiburner (OMB) coal-water slurry (CWS) entrained flow gasifier. The CWS gasification process is divided into several submodels, including water evaporation, coal pyrolysis, and homogeneous and heterogeneous char reactions. The "effectiveness factor" method is used to extrapolate the intrinsic char reactivity data to industrial CWS gasifier conditions. Numerical simulations with the proposed models are performed on the industrial OMB gasifier, and the predicted temperature and gas compositions at the outlet of the gasifier are in good agreement with industrial operating data. The profiles of flow field, temperature, and gas composition in the gasifier are described. In addition, the effects of the slurry concentration and oxygen/coal ratio on the gasifier performance are also studied, which reveal that the lower oxygen/coal ratio or higher slurry concentration leads to higher cold gas efficiency, while the carbon conversion slightly changes about 99%.