The reaction of the multidentate Schiff base species TrenSal, TrenBrSal, and TEtSal with copper acetate is reported. The hep, tadentate ligands generate a tetrametallic L2Cu4OH motif that contains an internalized hydroxide anion. In contrast, the hexadentate TEtSal ligand is found to form an open trimetallic motif. The importance of L2Cu4OH to the family of copper complexes with an endohedral hydroxide anion is discussed. [(TrenBrSal)2Cu(4)OH][OAc] is analyzed by temperature-dependent magnetic measurements.