A Ru-II-TAP Complex, Photoreagent for Tryptophan-Containing Peptides: Structure of the Covalent Photoadduct

Gauthier N; De Winter J; Gerbaux P; Moucheron C; Luhmer M; Kirsch-De Mesmaeker A

Inorganic Chemistry, Vol.49, No.15, 6796-6798, 2010

Gauthier N, De Winter J, Gerbaux P, Moucheron C, Luhmer M, Kirsch-De Mesmaeker A

We report the first structure determination of a covalent photoadduct between a Ru-II-tap complex and a tryptophan-containing peptide (AlaTrpAla) by mass spectrometry and NMR spectroscopy. Ru-II-tap complexes could thus be exploited as photodamaging agents of Trp-containing polypeptides or proteins.