Design and Synthesis of a Bombesin Peptide-Conjugated Tripodal Phosphino Dithioether Ligand Topology for the Stabilization of the fac-[M(CO)(3)](+) Core (M=(99) Tc-m or Re)

Kannan R; Pillarsetty N; Gali H; Hoffman TJ; Barnes CL; Jurisson SS; Smith CJ; Volkert WA

Inorganic Chemistry, Vol.50, No.13, 6210-6219, 2011

DOI10.1021/ic200491z Export Citation

Design and Synthesis of a Bombesin Peptide-Conjugated Tripodal Phosphino Dithioether Ligand Topology for the Stabilization of the fac-[M(CO)(3)](+) Core (M=(99) Tc-m or Re)

Kannan R, Pillarsetty N, Gali H, Hoffman TJ, Barnes CL, Jurisson SS, Smith CJ, Volkert WA

A new tumor-seeking tridentate topology consisting of a phosphino dithioether ((HOCH2)(2)PCH2CH2S(CH2)(n)CH2SR; PS2) ligand framework for the production of kinetically inert and in vivo stable facial [Tc-99m(CO)(3)(PS2)](+) or [Re(CO)(3)(PS2)](+) is described. The X-ray crystal structure of fac-Re(CO)(3)(PS2)PF6 is reported. The bioconjugation strategies for incorporating bombesin (BBN) peptides on to the PS2 tripodal framework and, thereby, de novo designing of GRP receptor-seeking Tc(PS2-BBN)(CO)(3) are developed.