Nearly all reported approaches for synthesis of high quality CdSe nanocrystals (NCs) involved two steps of preparation of Cd or Se stock solution in advance and then mixing the two reactants via hot-injection in high temperature. In this,manuscript, Gram-scale CdSe multipod NCs were facilely synthesized in a noninjection route with the use of CdO and Se powder directly as reactants in paraffin reaction medium containing small amount of oleic acid and trioctylphosphine. The influence of various experimental variables, including reaction temperature, nature and amount of surfactants, Cd-to-Se ratio, and the nature of reactants, on the morphology of the obtained CdSe NCs have been systematically investigated. After deposition of ZnS shell around the CdSe multipod NCs, the PL QY of the obtained CdSe/ZnS can be up to 85%. The reported noninjection preparation approach can satisfy the requirement of industrial production bearing the advantage of low-cost, reproducible, and scalable. Furthermore, this facile noninjection strategy provides a versatile route to large-scale preparation of other semiconductor NCs with multipod or other morphologies.