Hollow fibre membrane distillation (MD) modules have a more compact structure than flat sheet membrane modules, providing potentially greater advantage in commercial applications. In this paper, a high-flux asymmetrically structured hollow fibre MD module was tested under various conditions. The results show that increasing velocity and temperature are positive for flux, and salt rejection was more than 99% over the entire experimental range The hollow fibre module also showed great variation in flux when altering the hot feed flow from the lumen side to the shell side of the fibre, and this phenomenon was analysed based on the characterisation of the asymmetric structure of the hollow fibre The largest mass transfer resistance was determined to be in the small pore size skin layer on the outer surface of the membrane, and having the hot feed closest to this surface provided the greatest vapour pressure difference across this high resistance mass transfer layer. The results also show that placing the suction pump on the permeate outlet increased the flux by lowering the pressure within the pore and hence Increased the rate of vapour mass diffusion A maximum flux of 19 L m(-2) h(-1) was obtained at 85 degrees C when hot feed was entering the shell side, and the mass transfer coefficient was relatively constant across the entire temperature range when operated at high velocities. These outcomes suggest that asymmetric hollow fibre MD modules should be operated with hot brine feed closest to the high resistant skin layer, and that vacuum enhanced MD further increases vapour transport and flux (C) 2010 Elsevier B V All rights reserved.