The aggregation process in proteins is governed by several factors such as temperature, pH, presence of electrolytes, denaturants, and metal ions Here, we report the role of Cu(II) in inducing rapid fibrillation in human scrum albumin We have monitored this process via UV-vis spectroscopy, fluorescence spectroscopy, circular dichroism, zeta-potential measurements, electron paramagnetic resonance studies, fluorescence microscopy, and field emission scanning electron microscopy Images show a fibrillar network of human scrum albumin in the presence of Cu(II) in 60% ethanol incubated at 65 degrees C at physiological pH All other studies also support the enhanced fibrillation in presence of Cu(II)