The amine functional groups are fundamental building blocks of many molecules that are central to life, such as the amino acids, and to industrial processes, such as the alkanolamines, which are used extensively for gas absorption. The modeling of amines and of mixtures of amines with water (H2O) and carbon dioxide (CO2) is thus relevant to a number of applications. In this contribution, we use the statistical associating fluid theory for potentials of variable range (SAFT-VR) to describe the fluid phase behavior of ammonia + H2O + CO2 and n-alkyl-1-amine + H2O + CO2 mixtures. Models are developed for ammonia (NH3) and n-alkyl-1-amines up to n-hexyl-1-amine (CH3NH2 to C6H13NH2). The amines are modeled as homonuclear chain molecules formed from spherical segments with additional association sites incorporated to mediate the effect of hydrogen-bonding interactions. The SAFT-VR approach provides a representation of the pure component fluid phase equilibria, on average, to within 1.48% of the experimental data in relative terms for the saturated liquid densities and vapor pressures. A simple empirical correlation is derived for the SAFT-VR parameters of the n-alkylamine series as a function of molecular weight. Aqueous mixtures of the amine's are modeled using a model of water taken from previous work. The models developed for the mixtures are of high fidelity and can be used to calculate the binary fluid phase equilibrium of these systems to within 2.28% in relative terms for the temperature or pressure and 0.027 in absolute terms for the mole fraction. Regions of both vapor liquid and liquid liquid equilibria are considered. We also consider the reactive mixtures of amines and CO2 in aqueous solution. To model the reaction of CO2 with the amine, an additional site is included on the otherwise nonassociating CO2 model. The unlike interaction parameters for the NH3 + H2O + CO2 ternary mixture are obtained by comparison to the experimental data available for this system. The resulting model is found to correlate and predict the liquid-phase loading (moles of CO2 per mole of amine) to within 0.091 of experimental data in absolute terms. The parameters describing the NH3-CO2 interaction are then transferred to other n-alkyl-1-amines, and sample predictions of the fluid phase equilibria for the n-propyl-1-amine + H2O + CO2, n-butyl-1-amine H2O + CO2, and n-hexyl-1-amine + H2O + CO2 mixtures are presented. The latter mixture is found to exhibit regions of liquid liquid immiscibility.