The excitation and detection of high-order multiple quantum coherences among C-13 nuclear spins are demonstrated in the samples of [1-C-13]-L-alanine and C-13 labeled amyloid fibrils at a spinning frequency of 20 kHz. The technique is based on the double-quantum average Hamiltonian prepared by the DRAMA-XY4 pulse sequence. Empirically, we find that multiple supercycles are required to suppress the higher-order effects for real applications. Measurements for the fibril samples formed by the polypeptides of PrP(113-127) provide the first solid-state NMR evidence for the stacking of multiple beta-sheet layers at the structural core of amyloid fibrils