화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.20, No.9, 891-898, September, 2012
DOI10.1007/s13233-012-0134-y  Export Citation
Nanotechnology and Carbon Nanotubes; A Review of Potential in Drug Delivery
Edwin Kamalha†, Xiangyang Shi1, Josphat I. Mwasiagi2, and Yongchun Zeng
  • College of Textile Science and Engineering, Donghua University, 210620, Shanghai, P. R. China
  • 1College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 210620, Shanghai, P. R. China
  • 2School of Engineering, Moi University, Eldoret, Kenya
E-mail:
The need for affordable health care costs and the quest for better modes of treatment have increased research in novel drug delivery techniques. Efficient drug delivery systems (DDS) are judged on their ability to perform controlled and targeted drug delivery. Several nanomaterials such as carbon nanotubes (CNTs) are widely being investigated for biomedical use due to their unique properties, as well as several functional groups and incorporated targeting molecules. This review looked at nanotechnology as an emerging field in drug delivery. Several studies and findings with regards to the current functionalization of CNTs for drug delivery were explored. The conclusion reviewed the key notes.
Keywords:drug delivery systems (DDS);carbon nanotubes (CNTs);single-walled nanotubes (SWNTs);multi-walled nanotubes (MWNTs);functionalization.
  1. Uchizono JA, in Design of Controlled Release Drug Delivery Systems, Li X, Jasti BR, Eds., McGraw-Hill, New York, 10, 1 (2006)
  2. Urquhart J, Nichols K, Pharm. Tech., 9, 13 (1985)
  3. Thassu D, Deleers M, Pathak Y, in Nanoparticulate Drug Delivery Systems, Thassu D, Deleers M, Pathak Y, Eds., PharmaceuTech, Inc., Pinehurst, 166, 1 (2007)
  4. Gareth HA, J. Nanomed., 1, 2 (2005)
  5. Jiang W, Kim BYS, Rutka JT, Chan WCW, Expert Opin. Drug Deliv., 4, 621 (2007)
  6. Kim KY, Nanomedicine., 3, 103 (2007)
  7. Sinha N, Yeow JTW, IEEE Trans. Nanobioscience., 4, 180 (2005)
  8. Flynn GL, Pharm. Tech., 6, 33 (1982)
  9. Tomlinson E, in Drug Delivery Systems: Fundamentals and Techniques, Johnson P, Jones L, Eds., VCH Ellis Horwood Ltd, Chichester, 32 (1987)
  10. Kefalides PT, Ann. Intern. Med., 128, 1053 (1998)
  11. D'Aquino R, Chem. Eng. Prog., 100(2), 15S (2004)
  12. Bianco A, Wu W, Pastorin G, Klumpp C, Lacerda L, Charalambos DP, Kostarelos K, Prato M, in Nanomaterials for Medical Diagnosis and Therapy, Kumar C, Ed., WILEYVCH, Weinheim, 10, 85 (2007)
  13. Dubin CH, Mech. Eng. Nanotechnol., 126, 10 (2004)
  14. Courrier HM, Butz N, Vandamme TF, Crit. Rev. Ther.Drug Carrier Syst., 19, 425 (2002)
  15. LaVan DA, McGuire T, Langer R, Nat. Biotechnol., 21, 1184 (2003)
  16. Allen T, Cullis P, Science., 303, 1818 (2004)
  17. Desai MP, Pharm. Res., 13, 1838 (1996)
  18. Kohli AK, Alpar HO, Int. J. Pharm., 275, 13 (2004)
  19. Brzoska M, Langer K, Coester C, Loitsch S, Wagner TOF, Mallinckrodt CV, Biochem. Biophys. Res. Commun., 318(2), 562 (2004)
  20. Kohane DS, Tse JY, Yeo Y, Padera R, Shubina M, Langer R, J. Biomed. Mat. Res., 77, 351 (2006)
  21. Pastorin G, Expert Rev., 26, 750 (2009)
  22. Fahmy TM, Fong P, Park MJ, Constable T, Saltzman WM, AAPS J., 9, 171 (2007)
  23. Bianco A, Kostarelos K, Prato M, Curr. Opin. Chem. Biol., 9, 674 (2005)
  24. Pantarotto D, Briand JP, Prato M, Bianco A, Chem.Commun., 1, 16 (2004)
  25. Martin CR, Kohli P, Drug Discovery., 2, 29 (2003)
  26. Gao H, Kong Y, Cui D, Ozkan CZ, Nano Lett., 3, 471 (2003)
  27. Mamalis AG, Vogtlander LOG, Markopoulos A, Precision Eng., 28, 16 (2004)
  28. Becker L, Poreda RJ, Bunch TE, Proc. Natl. Acad.Sci. U.S.A., 97, 2979 (2000)
  29. Gogotsi Y, Naguib N, Libera JA, Chem. Phys. Lett., 365(3-4), 354 (2002)
  30. Kam NWS, O’Connell M, Wisdom JA, Dai H, Proc.Natl. Acad. Sci. U.S.A., 102, 11600 (2005)
  31. Panhuis M, Chem. Biol., 10, 897 (2003)
  32. Truskett TM, Proc. Natl. Acad. Sci. U.S.A., 100, 10139 (2003)
  33. Kalra A, Garde S, Hummer G, Proc. Natl. Acad. Sci.U.S.A., 100, 10175 (2003)
  34. Zhu F, Schulten K, Biophys. J., 85, 236 (2003)
  35. Li H, Wang DQ, Liu BL, Gao LZ, Colloids Surf. B:Biointerfaces., 33, 85 (2004)
  36. Foley S, Crowley C, Smaihi M, Bonfils C, Erlanger BF, Seta P, Larroque C, Biochem. Biophys. Res. Commun., 294(1), 116 (2002)
  37. Lin BY, Chyi SD, Wang HH, Yu PP, Kanakamma TY, Chou LCK, Ho LT, J. Neurochem., 72, 1634 (1999)
  38. Liu Z, Davis C, Cai W, He L, Chen X, Dai H, Proc.Natl. Acad. Sci. U.S.A., 105, 1410 (2008)
  39. Pantarotto D, Singh R, McCarthy D, Erhardt M, Briand JP, Prato M, Kostarelos K, Bianco A, Angew. Chem.Int. Ed., 43, 5242 (2004)
  40. Liu Y, Wu DC, Zhang WD, Jiang X, He CB, Chung TS, Goh SH, Leong KW, Angew. Chem. Int. Ed., 44, 4782 (2005)
  41. Singh R, Pantarotto D, McCarthy D, Chaloin O, Hoebeke J, Partidos CD, Briand JP, Prato M, Bianco A, Kostarelos K, J. Am. Chem. Soc., 127(12), 4388 (2005)
  42. Gao LZ, Nie L, Wang TH, Qin YJ, Guo ZX, Yang DL, Yan XY, Chem. Bio. Chem., 7, 239 (2006)
  43. Larouche F, http://www.nanotechnologies.qc.ca (Retrieved on 2011, Aug 02).
  44. Wu W, Wieckowski S, Pastorin G, Benincasa M, Klumpp C, Briand JP, Gennaro R, Prato M, Bianco A, Angew.Chem. Int. Ed., 44, 6358 (2005)
  45. Pastorin G, Wu W, Wieckowski S, Briand JP, Kostarelos K, Prato M, Bianco A, Chem. Commun., 11, 1182 (2006)
  46. Portney NG, Ozkan M, Anal. Bioanal. Chem., 384, 620 (2006)
  47. Ojima I, Acc. Chem. Res., 41, 108 (2008)
  48. Lee KM, Li LC, Dai LM, J. Am. Chem. Soc., 127(12), 4122 (2005)
  49. Coleman KS, Bailey SR, Fogden S, Green MLH, J. Am. Chem. Soc., 125(29), 8722 (2003)
  50. Umeyama T, Tezuka N, Fujita M, Matano Y, Takeda N, Murakoshi K, Yoshida K, Isoda S, Imahori H, J. Phys.Chem., 111, 9734 (2007)
  51. Georgakilas V, Kordatos K, Prato M, Guldi DM, Holzinger M, Hirsch A, J. Am. Chem. Soc., 124(5), 760 (2002)
  52. Tagmatarchis N, Prato M, J. Mater. Chem., 14, 437 (2004)
  53. Liu Z, Tabakman S, Welsher K, Dai H, Nano Res., 2, 85 (2009)
  54. Star A, Gabriel JP, Bradley K, Gruner G, Nano Lett., 3, 459 (2003)
  55. Gattia DM, Antisari MV, Marazzi R, Nanotechnology., 18, 255604 (2007)
  56. Constantine P, Firme MS, Prabhakar RB, Nanomedicine., 6, 245 (2010)
  57. Chen J, Liu HY, Weimer WA, Halls MD, Waldeck DH, Walker GC, J. Am. Chem. Soc., 124(31), 9034 (2002)
  58. Chen RJ, Zhan YG, Wang DW, Dai HJ, J. Am. Chem. Soc., 123(16), 3838 (2001)
  59. Gannon CJ, Cherukuri P, Yakobson B, Cognet I, Kanzius LJ, Kittrell SC, Weisman RB, Pasquali M, Schmidt HK, Smalley RE, Curley SA, Cancer., 110, 2654 (2007)
  60. Hu H, Ni Y, Montana V, Haddon RC, Parpura V, Nano Lett., 4, 507 (2004)
  61. Shao L, Lin TW, Tobias G, Green MLH, Chem. Commun., 2164 (2008)
  62. Simon F, Kuzmany H, Rauf H, Pichler T, Bernardi J, Peterlik H, Korecz L, Fulop F, Janossy A, Chem. Phys. Lett., 383(3-4), 362 (2004)
  63. Ren YP, Pastorin G, Adv. Mater., 20(11), 2031 (2008)
  64. Kataura H, Maniwa Y, Kodama T, Kikuchi K, Hirahara K, Suenaga K, Iijima S, Suzuki S, Achiba Y, Kratschmer W, Synth. Met., 121, 1195 (2001)
  65. Chen BH, Huang JH, Food Chem., 62, 299 (1998)
  66. Yudasaka M, Ajima K, Suenaga K, Ichihashi T, Hashimoto A, Iijima S, Chem. Phys. Lett., 380(1-2), 42 (2003)
  67. Mrzel A, Hassanien A, Liu Z, Suenaga K, Miyata Y, Yanagi K, Kataura H, Surf. Sci., 601, 5116 (2007)
  68. Yanagi K, Iakoubovskii K, Matsui H, Matsuzaki H, Okamoto H, Miyata Y, Maniwa Y, Kazaoui S, Minami N, Kataura H, J. Am. Chem. Soc., 129(16), 4992 (2007)
  69. Hampel S, Kunze D, Haase D, Kramer K, Rauschenbach M, Ritschel M, Leonhardt A, Thomas J, Oswald S, Hoffman V, Buchner B, Nanomedicine., 3, 175 (2008)
  70. Chaban VV, Savchenko TI, Kovalenko SM, Prezhdo OV, J. Phys. Chem., 11, 13481 (2010)
  71. Kam NWS, O’Connell M, Wisdom JA, Dai H, Mater.Sci. Eng. C., 19, 41 (2002)