The Maurice E. Muller Institute, embedded in the infrastructure of the Biozentrum, University of Basel, was founded in 1985 and financed by the Maurice E. Muller Foundation of Switzerland. For 26 years its two founders, Ueli Aebi and Andreas Engel, pursued the vision of integrated structural biology. This paper reviews selected publications issuing from the Maurice E. Muller Institute for Structural Biology and marks the end of this era. (C) 2011 Elsevier Inc. All rights reserved.