Journal of the American Chemical Society, Vol.133, No.21, 8134-8137, 2011
Enantioselective Dichlorination of Allylic Alcohols
The development of an enantioselective allylic alcohol dichlorination catalyzed by dimeric cinchona alkaloid derivatives and employing aryl iododichlorides as chlorine sources is reported. Reaction optimization, exploration of the substrate scope, and a model for stereoinduction are presented.