Journal of the American Chemical Society, Vol.133, No.27, 10352-10355, 2011
Catalytic Asymmetric C-H Insertions of Rhodium(II) Azavinyl Carbenes
A highly efficient enantioselective C-H insertion of azavinyl carbenes into unactivated alkanes has been developed. These transition metal carbenes are directly generated from readily available and stable 1-sulfonyl-1,2,3-triazoles in the presence of chiral Rh(II) carboxylates and are used for C-H functionalization of alkanes to access a variety of beta-chiral sulfonamides.