Oxo-Tethered Ruthenium(II) Complex as a Bifunctional Catalyst for Asymmetric Transfer Hydrogenation and H-2 Hydrogenation

Touge T; Hakamata T; Nara H; Kobayashi T; Sayo N; Saito T; Kayaki Y; Ikariya T

Journal of the American Chemical Society, Vol.133, No.38, 14960-14963, 2011

DOI10.1021/ja207283t Export Citation

Oxo-Tethered Ruthenium(II) Complex as a Bifunctional Catalyst for Asymmetric Transfer Hydrogenation and H-2 Hydrogenation

Touge T, Hakamata T, Nara H, Kobayashi T, Sayo N, Saito T, Kayaki Y, Ikariya T

Newly developed oxo-tethered Ru amido complexes (R,R)-1 and their HCl adducts (R,R)-2 exhibited excellent catalytic performance for both asymmetric transfer hydrogenation and the hydrogenation of ketonic substrates under neutral conditions without any cocatalysts to give chiral secondary alcohols with high levels of enantioselectivity.