Experiments were carried out by reacting H-2 gas with N-2 hydrate at a temperature of 243 K and a pressure of 15 MPa. The characterizations of the reaction products indicated that multiple H-2 molecules can be loaded into both large and small cages of structure II clathrate hydrates. The realization of multiple H-2 occupancy of hydrate cages under moderate conditions not only brings new insights into hydrogen clathrates but also refreshes the perspective of clathrate hydrates as hydrogen storage media.