The dynamics of the three-phase contact line for water and ethanol is experimentally investigated using substrates of various hydrophobicities. Different evolutions of the droplet profile (contact line, R, and contact angle, theta) are found to be dependent on the hydrophobicity of the substrate. A simple theoretical approach based on the unbalanced Young force is used to explain the depinning of the contact line on hydrophilic surfaces or the monotonic slip on hydrophobic substrates. The second part of the article involves the addition of different quantities of titanium oxide nanoparticles to water, and a comparison of the evaporative behavior of these novel fluids with the base liquid (water) on substrates varying in hydrophobicity (i.e., silicon, Cytop, and PTFE) is presented. The observed stick slip behavior is found to be dependent on the nanoparticle concentration. The evaporation rate is closely related to the dynamics of the contact line. These findings may have an important impact when considering the evaporation of droplets on different substrates and/or those containing nanoparticles.