In the present work, laminar mixed convection flow and heal transfer between two co-rotating disks with wall transpiration is investigated numerically. Both thermal boundary conditions of uniform heat flux (UHF) and uniform wall temperature (UWT) are considered. The Boussinesq approximation is invoked by taking into account the centrifugal buoyancy effects. The present paper particularly addresses the effects of wall transpiration, centrifugal buoyancy, Coriolis force, through-flow and wall-heating conditions. The numerical predictions reveal that either wall injection or wall suction has an appreciable effect on flow structure and heat transfer performance. In the case of hot-wall/cold-fluid (Gr(Omega) > 0), the centrifugal buoyancy has a suppression effect on the skin friction and heat transfer rates.